Tag Archives: depression

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women Women are twice as likely as men to suffer from a depressive disorder.  In addition, they are vulnerable to mood disorders associated with reproductive functioning, specifically premenstrual dysphoric disorder, perinatal depression, and perimenopausal depression. There is strong evidence to indicate that biological factors (genetic vulnerability,… Read More »

Essential Reads: Zuranolone for Postpartum Depression

In 2019, the Food and Drug Administration (FDA) approved brexanolone, marketed by Sage Therapeutics as Zulresso, as a treatment for postpartum depression (PPD).  As a neurosteroid, brexanolone represents a novel approach to the treatment of postpartum mood disorders.  One of the most exciting things about brexanolone is the rapidity of the response, with the initial… Read More »

Perimenopausal Depression in Women with More Variable Levels of Estradiol and Lower Progesterone Levels

Women are at increased risk for depressive symptoms during the menopause transition.  It has long been suspected that falling estrogen levels play a role in triggering the onset of depression; however, if all women experience declining levels of estrogen and progesterone during this transition, why is it that only some women suffer from depression in… Read More »

CBT-Based Group Intervention Improves Perinatal Depression and Maternal Sensitivity

Previous research has shown that higher levels of depressive symptoms during pregnancy may be associated with lower levels of maternal-fetal attachment (MFA).  Other studies have indicated that poor MFA is a significant predictor of worse outcomes in terms of mother-infant interactions and infant attachment security.  A new study looks at an intervention designed to treat… Read More »